We recommend spot cleaning with a mild soap (i.e. dish soap) and water. If this is not successful, try a product used for spot removal on clothing such as Spray 'n Wash, or using a foam type cleaner used to clean car mats or automobile carpets (sold at car parts stores). If the luggage has an offensive odor, use a vinegar (1 part) and water (5 parts) mixture. This may take the odor out but it will then need to be aired out for a few days. Also, we recommend placing charcoal in the bag for a day or more (depending on the strength of the odor) and close the bag. The charcoal will absorb the smell.